The Daily Gazette Sign up for daily emails to get the latest Harvard news. This is one in a series of profiles showcasing some of Harvard’s stellar graduates.Since childhood, Cynthia Luo knew she wanted to be a physician. In high school, she discovered a passion for cancer immunology research while working in the lab of a biotech company. After spending part of a gap year volunteering at a rural health clinic in Uganda, she aspired to have an impact on global health.At Harvard, she put all of these dreams together.After her first year, the Leverett House resident began working in the lab of Professor of Organismic and Evolutionary Biology and Professor of Immunology and Infectious Diseases Pardis Sabeti, and co-authored papers on the development of a new diagnostic test for Zika virus and for a method to test for Zika, chikungunya, and dengue.Luo would later co-author another paper, on the persistence of Ebola virus in bodily fluids, and is currently working with scientists in the lab on research aimed at harnessing CRISPR (a family of DNA sequences) tools for their antiviral potential. Her senior thesis explored the structure and evolution of Ebola virus RNA and has helped shed new light on how the virus interacts with its host.“When I came to college I sought out a lab that had direct translational clinical impact on global health,” Luo, a native of Cos Cob, Conn., said. “During my time in Uganda, I worked with people who experience health conditions that are sadly often not really talked about in the States since many infectious diseases are ‘eradicated’ here. In the U.S., HIV is no longer a death sentence for most people, but it’s a different situation there.”Before arriving at Harvard, Luo took a gap year so she could apply herself to a pair of projects. Part of the year, she devoted to completing research she’d begun at the biotechnology company Regeneron, where she had worked on cancer immunology and exploring ways to “rescue” the body’s immune system — which may not recognize cancer cells as invaders — and train it to attack the disease.“It’s really exciting work — I loved the creativity behind it, and it changed my mind a lot about what research could look like,” Luo said. “Before I did a lot of hands-on research, I thought I definitely wanted to go into medicine, because I thought research was boring … but that’s not the case at all. I was very excited about the collaborative atmosphere and about the incredible amount there was to learn, and I wanted a bit of extra time to do that.”Inspired by a high school trip to Central America, Luo spent the second half of her gap year volunteering at a rural health clinic in Uganda’s Mukono District.“I split my time between doing logistics for the clinic — like ordering meds, creating publicity initiatives, developing patient surveys — and accompanying nurses and social workers to different village outreach trips,” she said. “Through that — being able to see different clinics in Uganda, and having that understanding of the different health conditions people experience … when I came to college I was thinking about how to connect the experience I had in the lab with this global health work.”When the molecular and cellular biology concentrator isn’t in the Sabeti Lab, she is often volunteering with CrimsonEMS, Harvard’s student-run emergency medical service, and served as its chief in 2018.“I decided to become an EMT before college, and that was very much a super-personal decision,” Luo said, recalling a freak car accident that involved her mom.“She’s totally OK now, and I’m so grateful for that, but I was the person who found her and called 911,” she continued. “You don’t expect to see your mother in a position of such vulnerability and near death — I remember a chaplain actually came to talk to me at the hospital. The terror in that moment of not knowing what to do really stuck with me, but the fact that the EMTs came and knew what to do in that moment, and were calm in that moment of absolute terror was something that also stuck with me, so I got certified to pay it forward.”Luo applied as a sophomore to the Icahn School of Medicine at Mt. Sinai where she will begin in August. Knowing her post-college plan so early allowed her to spend more time in the lab and also fully embrace her secondary concentration, English.“Reading and the writing process really force you to put yourself in the shoes of someone whose life could be completely different from yours. Being able to be in that headspace is something that’s really important in medicine and in being a good human being,” she said. “The whole process of interpreting text and thinking about what’s not on the page has many parallels to when you’re doing a primary evaluation for a patient.”Her Harvard studies — in the classroom, the lab, and the ambulance — contributed to what Luo called “a blessed time.”“Being here has been about living in the present and making the most of every single part of what it means to call this place home,” she said. “The places and people I’ve been lucky enough to be involved with have taught me that there’s so much fulfillment to derive from wherever you are in life.”
Charles M. Lieber and Shaun Patel, a faculty member at the Harvard Medical School and Massachusetts General Hospital, see a field — their own — at a tipping point. In a perspective titled “Precision Electronic Medicine,” published this month in Nature Biotechnology, they argue that neurotechnology is on the cusp of a major renaissance.“The next frontier is really the merging of human cognition with machines,” said Patel, a neurologist at Harvard Medical School and Massachusetts General Hospital. And in their article, he and Lieber, the Joshua and Beth Friedman University Professor, write that mesh electronics such as those developed by Lieber are the foundation for machines designed to personalize electronic treatment for just about anything related to the brain.“Everything manifests in the brain fundamentally. Everything. All your thoughts, your perceptions, any type of disease,” Patel said.Right now, scientists can identify the areas of the brain where decision-making, learning, and emotions originate, but tracing behaviors to specific neurons is still a challenge. That means that when the brain’s complex circuitry becomes tangled or degraded by psychiatric illnesses such as addiction, neurodegenerative diseases like Alzheimer’s, or even natural aging, doctors have only two options: drugs or implanted electrodes, both of which can have effects on more than their intended targets. In some cases side effects can be severe, and while the effects of deep-brain stimulation can be almost instantaneous, over time the brain’s immune system treats the stiff implants as foreign objects: Neural immune cells (glia cells) engulf the perceived invader, displacing or even killing neurons and reducing the device’s ability to maintain treatment.Lieber and Patel believe the current technology is simply a stopgap. In their paper, they write that developing “research focused at the interface between the nervous system and electronics … [can unlock] the potential of implants capable of cellular-level therapeutic targeting.”“Personalized electronic therapies will provide new treatment modalities for neurodegenerative and neuropsychiatric illness; powerful control of prosthetics for restorative function in degenerative diseases, trauma and amputation; and even augmentation of human cognition,” they write. “Overall, we believe that emerging advances in tissue-like electronics will enable minimally invasive devices capable of establishing a stable long-term cellular neural interface and providing long-term treatment for chronic neurological conditions.”To that end, Lieber’s lab is designing smaller, more flexible electronic brain implants that move with brain tissue instead of against it. His mesh electronics mimic the size, shape, and feel of real neurons; can record, track and modulate individual neurons and circuits for up to a year or more; and provoke almost no immune response. In addition, Lieber’s electronics have already demonstrated a valuable trick of their own: They encourage neural migration, potentially guiding newborn neurons to damaged areas, like pockets created by stroke.What this means, the researchers said, is that eventually the technology could track how specific neural subtypes talk, which in turn could lead to a cleaner, more precise map of the brain’s communication network. With higher-resolution targets, future electrodes can act with greater precision, eliminating unwanted side effects. And, Patel said, they could be tuned to treat any neurological disorder.Lieber and Patel expect the next steps to be a focus on “highly flexible mesh probes with high densities of recording and stimulation electrodes [that can interface] with mature, silicone-based processor chips,” ultimately leading to “seamless neural-electronic systems,” even treatments for bedeviling and disheveling brain illnesses such as Alzheimer’s.After that, they said, adaptive electrodes could provide better control over prosthetic or even paralyzed limbs, and in time may act like neural substitutes, replacing damaged circuitry to re-establish broken communication networks and recalibrate based on live feedback.“If you could actually interact in a precise and long-term way and also provide feedback information,” Lieber said, “you could really communicate with the brain in the same way that the brain is communicating within itself.”Mesh electronics still has several major challenges to overcome: scaling up the number of implanted electrodes, processing the data flood those implants deliver, and feeding that information back into the system to enable live recalibration.“I always joke in talks that I’m doing this because my memory has gotten a little worse than it used to be,” Lieber said. “That’s natural aging. But does it have to be that way? What if you could correct it?”“The potential for it is outstanding,” Patel said. “In my own mind, I see this at the level of what started with the transistor or telecommunications.”
Show Closed This production ended its run on Aug. 21, 2016 Finding Neverland Related Shows View Comments The previously reported Broadway transfer of Finding Neverland will fly into the Lunt-Fontanne Theatre after Motown vacates the venue next year. Directed by Tony winner Diane Paulus, the new musical will begin previews in March 2015 with opening night set for April 8. No word yet on casting, but the recent American Repertory Theater production in Cambridge, Massachusetts, starred Tony nominee Jeremy Jordan as J.M. Barrie and Olivier winner Laura Michelle Kelly as Sylvia Llewelyn Davis. Finding Neverland will have scenic design by Scott Pask, lighting design by Phillip S. Rosenberg, costume design by Suttirat Larlarb and sound design by Jonathan Deans. The ART production’s cast also included Carolee Carmello, Michael McGrath and Jeanna de Waal. Tony nominee and Glee star Matthew Morrison previously starred as Barrie in an industry-only workshop of Finding Neverland in New York in late March. The tuner, which features music and lyrics by Gary Barlow and Eliot Kennedy and a book by James Graham, is based on the 2004 film written by David Magee. Finding Neverland follows the story of Barrie and his relationship with the family of widow Sylvia Llewelyn Davies. Llewelyn Davies’ children eventually became Barrie’s inspiration to write Peter Pan. The Harvey Weinstein produced musical overhauled its creative team in 2013, bringing on board Paulus, Barlow and Graham.
More Transmission Would Speed Coal Plant Closures Says German Regulator FacebookTwitterLinkedInEmailPrint分享Reuters:FRANKFURT—Germany could reduce its coal-fired power generation capacity by half in the coming years if planned grid expansion and the addition of new gas-fired plants come online on schedule, the head of its energy regulator said.“Half of coal-fired power plant capacity can disappear by 2030 without any risk to supply,” Jochen Homann, president of the Bundesnetzagentur or Federal Network Agency, told German daily Frankfurter Allgemeine Zeitung in an interview.His comments come ahead of a year-end deadline for a commission to submit plans to the German government for an exit from coal-fired energy. Germany aims to raise wind and solar power’s energy share from a third now to 65 percent by 2030 to help to cut carbon dioxide emissions and achieve its climate commitments, in line with the wishes of the new coalition government.Homann reiterated that grid expansion would be needed to meet those goals. “If you want more green energy faster, then you have to accept grid expansion,” he told the paper.He said the lack of grid capacity is likely to have raised the cost of ensuring a stable energy supply system to a record of more than 1 billion euros ($1.18 billion) in 2017.More: Germany Could Shut Down Half Of Its Coal Capacity: Regulator
5SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr continue reading » No longer just a luxury, speed has quickly made the transition from being a ‘nice-to-have’ to a ‘need-to-have’ across all industries. The demand for instant gratification has made retailers rethink delivery options. Smartphone apps have changed the way consumers connect with taxi alternatives, make a reservation at a restaurant and even arrange a date. Entertainment can be streamed to a TV or a phone in seconds. Consumers are becoming less patient.This need for immediate gratification has also impacted the banking industry. Spurred on by a surge in banking innovation, a new generation of consumers continue to raise expectations to greater heights. Long wait times and limited customer service options are quickly falling out of favor as new technology — such as mobile banking apps, peer-to-peer transfer services and online banking — responds to a consumer base that is perpetually impatient.Millennial consumers specifically often trade face-to-face interactions at their local bank branch for the speed and convenience of digital alternatives. In fact, mobile banking transactions are expected to more than double by 2022, while visits to retail bank branches may decline as much as 36% during the same time frame. And it is not just the Millennial generation. Consumers of all ages are increasingly choosing digital alternatives rather than visiting a branch.
Croatian tourism will lack about 15.000 workers next year, and the only solution to the whole story is to solve the cause of it – and that is to improve working conditions and increase wages. Nothing new or revolutionary, but the main problem has been pushed on the carpet for years, and now that the whole situation has escalated, when there is a chronic shortage of labor in tourism, we have all sorts of extremes and anomalies.And the situation has escalated so much that even the Minister of Tourism a few days ago publicly called out hoteliers that they have to raise salaries by 30 percent.Should the state reduce the tax rate in tourism and is it possible to increase 30 percent higher salaries for workers in the tourism industry, which raised employers to their feet, the director of the Tourism Department at the Croatian Chamber of Commerce spoke on HRT in Tema dana Želimir Kramarić and long-time president of the Union of Hoteliers and Caterers of Istria, Kvarner and Dalmatia Bruno Bulić.Compared to tourism competition, Croatia has one of the highest VAT rates in the EU. That is a fact and no one can dispute it. Spain and France have a rate of 10 percent for hotel accommodation and catering, Portugal an incredible 6 percent, Slovenia 9 and a half percent. Croatia holds high with a 25 percent VAT.With such benefits, large tourist companies in Croatia make higher profits than the same companies in Spain, Italy, etc. It is not true what employers claim, the data should be analyzed, said Bruno Bulić. He stated that some companies have a net profit of around 30 million to 700 million kuna. “I think they learned a lot of money and big profits and acquisitions. The state as a stabilizer between the insatiability of capital and the position of workers in this activity has not played its role”, Said Busic and added that he believes that dangerous concreting and apartmentization are happening because of a lot of money – and incompetent local governments have a big role in that, he believes.”For many years in tourism and in the overall economy we have had a key competitiveness problem due to labor issues. The fact is that employers are raising wages and will continue to do so. But in order to go further – there must be relief: labor costs through lower benefits, equalization of conditions with competing countries and investment in people., said Želimir KramarićCommenting on the fact that some hotels have been raising the salaries of waiters (HRK 7.000), maids and cleaners (HRK 5800 to 6200) for years and providing accommodation and two meals with the salary, Bulić said that this was the result of the functioning of the labor market in tourism. “The share of labor in total income in tourism ranges from 23 to 28 percent. Competing countries have that much larger share. We can’t just talk about taxes. Workers in tourism would not leave if they did not have a higher salary there. They must be higher and workers need to be employed indefinitely”, Concluded Busic.The show pointed out that Slovenians raised the average salary in tourism to 1.000 euros, and ‘introduced’ workers from Croatia, and K ramarić also mentioned the education of staff in tourism as key, and that we cannot live only from the sun and the sea, but we should develop other content as well.Throughout the story, it is quite clear how to raise wages and working conditions, as well as that the State must reduce VAT in tourism as well as other levies that burden entrepreneurship. Shooting through the media really doesn’t make sense, you need to sit down at a table and find the best solution. It is a well-known fact that the lower the taxes and levies, the more entrepreneurship flourishes. Win-Win.Source: HRT
Jet fuel consumption in Indonesia has slumped as a result of nosediving air travel because of the COVID-19 pandemic.Data from state-owned oil company Pertamina show that the average daily consumption of aviation fuel during the period of March 1 to April 14 was down 45 percent from the January-February period. In March alone, daily average consumption of aviation fuel plunged 60 percent compared to the previous month.“This is staggering. A 60 percent decline in avtur consumption was caused by suspensions in most domestic and international flights,” said Pertamina president director Nicke Widyawati on Wednesday. With the sharp drop in sales, Pertamina’s stock of jet fuel would be enough for the next 119 days, said Nicke, prompting the company to consider exporting avtur.The Indonesian National Air Carriers Association (INACA) previously reported that national airlines had slashed flights, frequency by 50 percent or more, as airlines continued to see steep drops in passenger numbers due to the pandemic, which has forced several countries to impose travel bans. Low-cost carrier AirAsia Indonesia has temporarily halted all of its flight services since April 1.The number of air passengers has declined accordingly. There were only 5.79 million domestic passengers in February, down by 8.08 percent from January, Statistics Indonesia data show.The number of international flight passengers, meanwhile, plummeted to 1.1 million people in February, which is down more than 33 percent from January.Topics :
Nineteen-year-old Warren Tanoesoedibjo, son of business tycoon Hary Tanoesoedibjo, was named the winner of an electric motorcycle owned and signed by President Joko “Jokowi” Widodo after he agreed to match the winning bid of Rp 2.55 billion (US$178,037).Warren had been the second-highest bidder in the auction, which was held during a virtual charity concert on May 17.The initial winner, a Jambi construction worker named M. Nuh, failed to pay for the motorcycle, saying he was unaware that he was participating in an auction. “He thought he had won [the motorcycle] as a gift at the charity event,” Jambi Police chief Insp. Gen. Firman Santyabudi said on Thursday.The virtual charity concert organizer, Olivia Zalianty, then contacted Warren to see if he still wanted to buy the motorcycle.“It turned out he was only 19 years old and said he really wanted to buy the motorcycle with the President’s signature,” Olivia said in a press conference on Friday. “And he was prepared to buy it for the same price as the winning bid.”Hary, who represented Warren at the press conference, said his son had asked his permission to take part in the auction.“He asked my permission to use his savings for the charity auction. I told him to go ahead if he wished to do so,” Hary said.Topics :
48 McDonald St, Hawthorne.Two crystal chandeliers hang from 6m-high vaulted ceilings in the impressive entry foyer. Natural light flows through clerestory windows, highlighting the Sydney blue gum timber flooring. A large carpeted office sits to one side with built-in cabinetry and work desks, data cabling, and private entry to the front veranda. 48 McDonald St, Hawthorne.THIS bespoke property is the direction architect Kevin Hincksman sees modern Aussie homes going. Occupying a 744sq m block in Hawthorne’s River Avenues precinct, the exterior of the 48 McDonald St home instils a sense of peace, combining dark timber and stone with pebbled pathways and established gardens. 48 McDonald St, Hawthorne.The covered rear deck promotes dining with an outdoor kitchen featuring built-in barbecue, Condour rangehood, sink and bar fridge. Rich timber decking runs to the edge of an in-ground pool and a fenced back yard. The ground floor also includes a laundry, discreet and modern bathroom, and a media room with in-ceiling surround sound and blackout curtains.All four bedrooms are located on the first floor, encircling a naturally-lit family room with polished timber flooring. 48 McDonald St, Hawthorne.More from newsMould, age, not enough to stop 17 bidders fighting for this home2 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor8 hours agoThe open-plan living and dining rooms embrace the residence’s focus on space while showcasing elements of opulence. A built-in television sits above a contemporary gas fireplace in the living room, and sliding glass doors offer seamless access to the pool and back veranda. Waterfall Caesarstone benchtops, Miele appliances, soft-close cabinetry and a drinks preparation station with a Vintec wine fridge accentuate the kitchen’s functional and aesthetic appeal. The enormous butler’s pantry makes hosting easy, thanks to stone benchtops and a built-in dishwasher. 48 McDonald St, Hawthorne.The main bedroom boasts a custom walk-in wardrobe and ensuite. The latter includes a double vanity, bathtub and oversized shower with dual showerheads. The other bedrooms come with built-in wardrobes and study desks, along with ducted airconditioning. A shared bathroom sits nearby.Significant storage space is available in the garage, which boasts a custom-built work bench.“This property stands for quality, individuality, thought and craftsmanship,” agent Darcy Lord of Place Bulimba said.The home is open for inspection by appointment with an auction on site set for 10am February 25.