Glaxo H5N1 vaccine may work against multiple strains

first_imgEditor’s note: This story was revised Mar 7 to clarify information about global influenza vaccine production capacity.March 6, 2007 (CIDRAP News) – The British pharmaceutical company GlaxoSmithKline (GSK) unveiled new findings yesterday suggesting that its inactivated H5N1 influenza vaccine may protect humans from more than one strain of the virus, which may build a stronger case for prepandemic vaccination and spur more countries to consider stockpiling.Researchers from GSK detailed recent findings from two studies at a symposium in Hong Kong, the company said in a press release yesterday. In July 2006, the company had reported that its vaccine triggered a good immune response in humans at a much lower dose than other H5N1 vaccines under development.GSK’s vaccine, based on an H5N1 virus collected in Vietnam in 2004, contains a proprietary adjuvant (an immune-stimulating chemical). Adjuvants enable vaccine makers to produce more doses from a limited supply of antigen.Though the GSK vaccine is made with older egg-based production methods, which are slower and more laborious than newer cell-culture or DNA technology, the dose-sparing effect of the adjuvant is crucial. The current world population is more than 6 billion, but the World Health Organization (WHO) has estimated the maximum global production capacity for seasonal flu vaccines at only about 350 million doses.In November, the WHO cautioned governments against spockpiling prepandemic vaccines, because many fundamental questions about H5N1 vaccines remained, such as whether vaccines would work against more than one strain of the virus.However, vaccines that are effective against more than one strain could strengthen the case for building prepandemic vaccine stockpiles. David Stout, president of GSK Pharmaceuticals, commented in the press release, “We believe this vaccine will provide governments with a new option to help protect their populations against the threat of a future human influenza pandemic.”Study resultsThe first study GSK presented at the Hong Kong meeting involved 400 adults and found that very low levels of GSK’s inactivated, adjuvanted H5N1 vaccine (two 3.8-microgram [mcg] doses administered 21 days apart) elicited strong cross-reactive immunity against an Indonesian strain of the virus. The response was 25 times greater than that observed in a control group that received a nonadjuvanted version of the vaccine, GSK said in its press release. Immunity was assessed by measuring the level of neutralizing antibodies.”This means that proactive administration of our prepandemic vaccine before or just after the start of a pandemic could help to substantially slow down the spread of the disease,” said Jean Stephenne, president of GSK Biologicals.For comparison, an H5N1 vaccine made by Sanofi Pasteur that was recently recommended for approval by a US Food and Drug Administration panel required two 90-mcg doses to yield an immune response in less than half of patients tested.In the second study, researchers immunized ferrets with the GSK vaccine and then infected them with an Indonesian strain of H5N1 virus. Only 1 of the 23 infected animals died, which translates to a 96% protection rate, GSK reported.Findings difficult to evaluateGregory Poland, MD, a vaccine expert at the Mayo Clinic in Rochester, Minn., told CIDRAP News that it’s hard to evaluate GSK’s findings, because the company has not yet published any clinical trials in peer-reviewed medical journals. “It’s certainly exciting news, but it needs to be confirmed,” he said. Researchers are eager to learn more about the adjuvant that GSK used, particularly its safety profile and reactivity.The report of a robust immune response with a low dose of vaccine is promising, and in a prepandemic setting, a two-dose course isn’t likely to be problematic, said Poland, who is a professor of medicine in infectious diseases at the Mayo College of Medicine and directs the Mayo Vaccine Research Group and Program in Translational Immunovirology. “It’s tempting to go overboard, and I’m excited, but cautiously so,” he added.Besides positioning its vaccine as a prepandemic measure for national stockpiles, GSK would also like to market the vaccine someday to medical clinics and individuals, according to a Canadian Press story published yesterday.In November 2006, the US Department of Health and Human Services awarded GSK a $40 million contract for a supply of its H5N1 antigen in bulk form, and in January it granted the company $63.3 million to develop antigen-sparing H5N1 influenza vaccines.See also:Jul 2006 CIDRAP News article “Glaxo says its H5N1 vaccine works at low dose”last_img read more

Tremmel extends Swans stay

first_img “Since the first day I joined this club, I knew something special was happening,” said the German, who joined the club in 2011. “I have been at a number of clubs, but the feeling here between the players, staff and supporters is different. “I feel very, very good here. Of course, last season I didn’t play the amount of games I had hoped for, but this season has been a completely different story on the pitch for me. “I have played in a lot more games and big matches against the likes of Manchester City, Chelsea, Arsenal and Liverpool to name but a few. “I think it has been good for myself and the supporters. I’ve been able to build momentum with a consecutive run of games this season, while the fans can now see what I am capable of. “I am contributing a lot more, which is great, and when the opportunity came along to sign a new deal here I was very happy to do that. “The club has been on a remarkable rise over the last few years, and it really is a nice story – I was keen to be a part of that story, so the new contract is great news for me because I feel I have a lot more to give this club.” The 34-year-old’s new contract, which includes the option of a further year, comes in the same week as midfielder Leon Britton and defender Garry Monk put pen to paper on extensions with the south Wales club. Tremmel only made a handful of first-team appearances under Brendan Rodgers, but has deputised admirably for Michel Vorm during the current campaign and has helped the Swans reach their first major cup final after keeping two clean sheets in the Capital One Cup semi-final success over European champions Chelsea. Press Associationcenter_img Goalkeeper Gerhard Tremmel has become the latest player to commit his future to Swansea after signing a new two-and-a-half-year deal at the Liberty Stadium.last_img read more

Despite blowout losses, Syracuse’s offensive performances have improved

first_img Comments On Oct. 7, No. 3 North Carolina was smothering Syracuse. The Tar Heels held a two-goal advantage, had nine shots, and if not for a penalty kick save by SU goalkeeper Jordan Harris, would have scored three goals with three-quarters of the game left to play.Still, Syracuse had a temporary breakthrough. Taylor Bennett launched a free kick from deep within SU’s defensive half to the Tar Heels’ penalty area, where Kate Hostage delicately flicked it on to the feet of UNC defender Julia Ashley. Ashley let it run, Meghan Root snuck behind her mark, and the freshman’s close-range finish was tidy. The Orange was within one goal against one of the nation’s best teams.“As a team we needed to be a little scrappier in the box, a little more hungry,” Root said. “And we need to do it a lot more consistently throughout the game.”Syracuse (3-12, 0-7 Atlantic Coast) conceded five unanswered goals following Root’s goal, in an eventual 7-1 loss, marking the sixth time it has allowed four or more goals this year. In its last three games, SU has scored five of its 11 goals on the season but surrendered 18. The Orange’s attack has come to life after a scoreless run in four games from Sept. 16 to 29, but Syracuse’s inability to keep games close has made its goals insignificant.After Kate Hostage’s goal in the 41st minute against Kent State on Sept. 13, SU’s offense went cold. First, it was a 4-0 loss to then-No. 13 Duke, a game in which Hostage, the team’s leading scorer, went down with a left ankle injury that sidelined her for the next three games. Four days later, Boston College held the Orange scoreless again in a dominant 3-0 win.AdvertisementThis is placeholder textSyracuse’s next two contests, both 1-0 losses, were “bad losses to take,” SU head coach Phil Wheddon said. First, the Orange conceded with nine seconds left in the game to then-one loss Louisville. Six days later, SU fell to Miami, who was winless in its previous seven games.“To lose those games against Louisville and Miami were gutting for us,” Wheddon said. “We honestly felt we should have got something out those games.”In the Orange’s next game against then-No. 23 North Carolina State, the drought finally ended, 423 game minutes after Hostage’s goal against Kent State. When Sydney Brackett’s corner kick snuck inside the front post and into the net in the third minute, SU celebrated like it was a last-minute winner.“I think you could see it in our reaction,” Root said. “All of us were sprinting and smiling and celebrating. There was just relief on our faces because we know we’re capable of scoring.”While Syracuse’s lead lasted just seven minutes, simply seeing the ball go into the net instilled SU with the belief that it could keep scoring, Brackett said. The Orange went on to score twice more that night.The increase in offensive production has been a result of SU pressing higher up the field with a 4-3-3 formation. On Saturday against Notre Dame, Wheddon started the second half with a high press. It worked for the first 25 minutes of the half, as the Orange dominated possession and scored a goal.“We’ve made creative runs and have had an offensive mindset,” Brackett said about SU’s recent offensive success. “A lot of the things that we’ve been talking about and working on in practice have finally started to translate onto the field.”But Syracuse’s offensive surge ended immediately following its goal. Over the final 20 minutes, the Fighting Irish took advantage of Syracuse’s offensive desperation and scored three goals en route to a 5-1 victory.While the Orange’s goals haven’t led to wins, they’ve proved SU can score against the conference’s best. Syracuse will have another opportunity to prove that on Thursday when it faces Virginia, who has allowed a conference-low seven goals this season.“We’re happy to be finding the back of the net,” Wheddon said. “But we’ve got to make sure that we close out games so we can win games.” Published on October 16, 2018 at 10:39 pm Contact David: [email protected]center_img Facebook Twitter Google+last_img read more

2005 ASICS NTL- OPENS & 20’S DAY TWO SUMMARY

first_imgDay two at the 2005 Asics National Touch League heated up in both competition and weather. It may sound corny but it’s definitely the truth. Many of the teams had at least two games today, if not three, and there were certainly some struggling to maintain the pace and the skills in the Coffs sun. Day two saw some cracker matches, with the `match of the timeslot’ (see reports in the results story) providing all the spectators down at the Coffs Harbour stadium with some top class competition. MENS OPEN: In Pool A the Rustlers steal top spot from the Suns after a narrow one touchdown victory in their round match after a controversial touchdown right on the siren. The Rustlers, Hornets, Suns and Mets look like they will be the four sides to qualify for the quarters, with the Mets sitting in fourth now and facing a difficult quarter final if they can’t move one or two places up the ladder tomorrow. Pool B looks like it will be close and tough, with the Sharks and Scorpions guaranteed quarter final spots, while the Cobras and Cyclones look likely to go through. For the Barbarians though, a win over the Cobras tomorrow morning may just get them into the quarters. The Sharks remain undefeated; their 5-4 win over rivals the Cobras was one of the matches of the day and sets up a great finals race between some traditional rivals. WOMENS OPEN: In Pool A the North Queensland Cyclones remain undefeated, somewhat of a surprise for pre-tournament punters. The Hunter Western Hornets have crept in front of the Sharks women, another surprise and the Suns are very close to missing out on a quarter final spot. Both the ACT and Eagles are yet to win a match; their clash will no doubt be eagerly awaited. The 3-3 draw played out between the Cobras and Mets sees those sides sitting on top of the ladder in pool B, with the Barbarians and Crusaders filling up the top four sides. Bo De La Cruz is back on the field for the Barbarians after injuring her ankle, and while definitely not at her best, she makes a big difference with her leadership and experience. After a strong start yesterday, the Crusaders went backwards on day two with two losses and one draw against the Scorpions 4-4. The Scorpions are sitting at the bottom of pool B’s ladder, yet to win a match, while the Rebels recorded their first win, against the struggling Scorpions unfortunately. MIXED OPEN: After six rounds the Mixed Open competition is a very even affair, with at least four sides quite capable of winning the event. The Sharks, Mets, Cobras and Scorpions all look strong and the match of the day no doubt was the Mets one touchdown win over the Sharks. The Sharks have been tipped to win the competition and certainly look to be capable of doing so. The Cobras 7-5 win over the Scorpions was another great match, with both sides showing they have the potential to match the Mets and Sharks. The ACT, Barbarians and Rustlers are struggling at the bottom of the ladder, but will be looking to improve over the final two days of competition. MENS 20 YEARS: Pool A appears to be a fairly tight affair, with several sides capable of winning on their day. The Suns look in the best form, especially after an easy win over the Brisbane Cobras. The Sharks and Eagles played out a close match earlier in the day and look to be sides capable of winning the title if they can put in a good performance. The Eagles will need to be on their game tomorrow, as they sit just ahead of the Hunter Western Hornets for the final spot in the quarter finals. The Eagles look to have an absolute pile of talent and by far the fastest team in the competition but haven’t been able to put it all together for an entire match against quality opposition yet. The ACT are struggling in what looks to be the tougher of the two pools, but with a young side will no doubt improve in the years to come. In Pool B the Rustlers and Sydney Mets drew to keep them both at the top of the ladder, adding another two sides more than capable of challenging pool A leaders, the Southern Suns. The Sydney Rebels are struggling, yet to win a match while the Crusaders’ win over the Rebels may just guarantee them a quarter final spot, albeit against the top finishing pool A side! The Cyclones looked promising this morning, with a 15-3 win over the Rebels but they then crumbled to a 12-2 defeat at the hands of the Mets. They will want to hold onto third position for the quarter finals. WOMENS 20 YEARS: In Pool A it is a Queensland affair with the Brisbane Cobras and South Queensland Sharks both yet to lose a match. The Sharks are looking the strongest, having only let in 7 touchdowns for the whole tournament. With the Crusaders and Scorpions both yet to win a match, it looks as though the Sydney Mets and the Cyclones, who have won two games and lost two games, will make it through to the quarter finals. After a slow start in pool B yesterday, the Southern Suns have climbed to the top of what is a very even and complicated ladder, sitting there with the local Northern Eagles, who after a close 5-4 win over the Rebels are looking promising for local fans. The Hornets, ACT and Rebels will all be fighting tomorrow for the final two spots in the quarter finals, making it a very interesting final day before the finals begin. By Rachel Moyle, [email protected].com.au WEBSITES: The 2005 Asics National Touch League Sporting Pulse website contains the final draws, results and also statistics such as touchdown scorers. Please use the following link: 2005 NATIONAL TOUCH LEAGUE DRAWS & RESULTS All feature articles will be placed on the www.austouch.com.au homepage and also on the above Sporting Pulse page as often as possible.last_img

a month agoLille sensation Osimhen: I’m not here to replace Pepe

first_imgLille sensation Osimhen: I’m not here to replace Pepeby Paul Vegasa month agoSend to a friendShare the loveVictor Osimhen is eager to avoid comparisons with Nicolas Pepe at Lille.Pepe left LOSC for Arsenal as Osimhen arrived from Charleroi.With five goals in five Ligue 1 games, the Nigerian striker is following in Pepe’s footsteps and said, “I have a lot of respect for Nicolas Pépé, for all that he brought to the club. “Many people think that I am replacing him but I am here with another name and to write my own story. “We have different profiles, we are not the same players. About the authorPaul VegasShare the loveHave your saylast_img

7 days agoMan Utd chief Woodward: Ole’s 3-point vision we share

first_imgAbout the authorPaul VegasShare the loveHave your say Man Utd chief Woodward: Ole’s 3-point vision we shareby Paul Vegas7 days agoSend to a friendShare the loveManchester United vice-chairman Ed Woodward insists the board are fully behind manager Ole Gunnar Solskjaer.Woodward has given his full backing to Solskjaer, despite the dismal run the Norwegian has endured since getting the job full-time.“Ole’s vision maps exactly to the core three football objectives we have,” said Woodward.“We must win trophies, we must play attacking football and we must give youth its chance.“Last season we were the Premier League’s leading club in terms of the most match minutes given to our own Academy graduates.“We should all be proud that the significant investments we have made in our Academy – spanning recruitment, facilities and analytics – are now bearing fruit.“There’s a lot more we need to do in that but that’s coming in the next few years.“We know this is a strong competitive advantage for us and an area that we’ll continue to focus on and invest in. But this remains the heart of the club.“The middle section of last season, after Ole’s arrival, feels most relevant to what we want to achieve and where we want to be.“We saw a team playing fast, fluid football, with a clear representation of the style and philosophy the manager wants.“Ole has also instilled the discipline back into an environment where we may have lacked it in recent years.“He’s building a squad that respects the club’s history, in which players work hard and respect their team-mates. No-one is bigger than the club.” last_img read more

PHOTOS: Minister Bartlett at Tourism Linkages Network Chef Workshop

first_imgMinister of Tourism, Hon. Edmund Bartlett (left), exchanges greetings with Chairman, Tourism Enhancement Fund (TEF), Godfrey Dyer (centre), during the Tourism Linkages Network’s chef workshop at the Liguanea Club in New Kingston on May 9. Sharing the moment is Executive Director, TEF, Dr. Carey Wallace. The workshop was held for junior culinary ambassadors and select members of the Culinary Federation of Jamaica, before they depart the island to compete in the annual Taste of the Caribbean competition in Miami in June.last_img

Highlights from Ontarios fall economic statement

first_imgTORONTO – Ontario’s Liberal government released a fall economic update Tuesday that included a tax cut for small businesses as an offset for a minimum wage that will rise to $14 an hour on Jan. 1, and $15 an hour the following year. Here are some highlights:— The corporate income tax rate for small businesses will be lowered from 4.5 per cent to 3.5 per cent on Jan. 1.— Small businesses with fewer than 100 employees that hire young workers (aged 15 to 29) will get incentives of $1,000 and another $1,000 for retaining that worker for six months.— Producers of locally grown fruits and vegetables will get $60 million in supports.— An apprenticeship training tax credit will be turned into a grant, giving employers $2,500 upon an apprentice’s completion of both level one and level two, $3,500 for completion of levels three and four, and $4,700 when the apprentice gets certification.— The apprenticeship grant would be available to all trades eligible for the current tax credit, as well as in five additional trades: hairstylist, cook, horticultural/landscape technician, baker and appliance service technician.— The legislation takes a preliminary step toward allowing Ontario’s nine Indigenous institutes to award degrees or diplomas on their own.— The government will put $85 million toward mercury remediation in the English-Wabigoon River system, which has affected the Grassy Narrows community for decades, through a trust that will be set up in collaboration with First Nation communities.— Real GDP growth is forecasted to be 2.8 per cent this year, up from the 2.3 per cent projected in the spring budget.— Net-debt-to-GDP ratio is projected to fall to 37.3 per cent this fiscal year— Interest on debt, which is currently about $312 billion, is projected to grow from about $12 billion now to $13.3 billion in 2019-20.— A moderating housing market has left the government with about $300 million less in land transfer tax revenues since projections in the spring budget.last_img read more

Athenahealth fetches 57 billion cash buyout offer

first_imgAthenahealth shares soared Monday after the struggling medical billing software maker received a $5.7 billion cash buyout offer.Veritas Capital and Evergreen Coast Capital plan to give athenahealth shareholders $135 per share in a deal that will take the company private. That represents a roughly 12 per cent premium over the closing price of athenahealth shares on Friday.But the latest deal is smaller than a $6.5 billion bid that prominent investor Elliott Management Corp. made in May.Elliott Management made its offer for $160 per share in cash after saying it had grown frustrated with athenahealth’s struggles, which included missed guidance targets and churning through five chief financial officers in the last four years.A month after Elliott made its offer, co-founder and CEO Jonathan Bush said he was stepping down.Athenahealth said Monday that Elliott Management supported the latest deal offer. Evergreen Coast Capital is an Elliott affiliate that invests in technology.Athenahealth, based in Watertown, Massachusetts, makes medical record, revenue cycle and care co-ordination products and delivers most of it through the cloud. On Friday, it reported third-quarter earnings that topped analyst expectations, but its revenue fell short of the average forecast on Wall Street.The latest athenahelath bid offers “a decent valuation for what has increasingly appeared to be a struggling business,” Leerink analyst David Larsen said in a research note.“We believe that following the long and tumultuous sales process it is unlikely another bidder will emerge,” he wrote.Evergreen and Veritas plan to pair athenahealth with Virence Health, which Veritas bought earlier this year. The combination will operate under the athenahealth brand and stay headquartered in Watertown, Massachusetts. Virence Chairman and CEO Bob Segert will lead it.Athenahealth’s board of directors unanimously approved the deal, which the company expects to close in the first quarter. Shareholders still have to vote on it.Athenahealth stock jumped about 9.5 per cent, to $131.73 while broader indexes slipped Monday morning.last_img read more

Hazare hails news of former SC judge Ghose being tipped for Lokpal

first_imgMumbai: Social activist Anna Hazare Sunday welcomed the news that former Supreme Court judge Justice Pinaki Chandra Ghose was being considered for appointment as the chief of country’s first Lokpal, the anti-corruption ombudsman. Justice Ghose, who retired from the Supreme Court in May 2017, is a member of the National Human Rights Commission (NHRC). Speaking to reporters, Hazare said, “I welcome the decision of appointing the country’s first Lokpal. The people’s movement for it, going on for 48 years now, has finally won.” Also Read – Squadrons which participated in Balakot air strike awarded citations on IAF Day Hazare has led several agitations and hunger protests demanding the appointment of Lokpal at the national level and Lokayukta in states. He had sat on a hunger strike in February-March in his native Ralegansidhi in Ahmednagar district over the non-appointment of Lokpal. The Lokpal Act, which envisages establishment of anti-graft body Lokpal at the Centre and Lokayuktas in states to look into cases of corruption against certain categories of public servants, was passed in 2013.last_img read more